Cre recombinase is a 38 kDa site‑specific recombinase derived from P1 bacteriophage that catalyzes precise DNA recombination between pairs of 34 bp loxP recognition sites, enabling efficient deletion, inversion, or insertion of floxed DNA segments in eukaryotic genomes. As a gold‑standard tool for genome engineering, the Cre/loxP system is widely used to perform conditional knockouts, knock‑ins, and cell‑lineage tracing in cultured cells and diverse animal models.
Cre mRNA is engineered for optimal performance. Manufactured via in vitro transcription (IVT), our mRNA features a Cap1 structure and a Poly(A) tail to mimic natural mature mRNA, ensuring superior stability and translation efficiency. Furthermore, the incorporation of modified nucleotides significantly reduces innate immune responses, enabling high-level expression and safer application in diverse cell types.